For what duration should Trimethoprim be taken as first-line treatment for UTIs in the third trimester?

Trimethoprim, as a first-line treatment for urinary tract infections (UTIs) during the third trimester of pregnancy, is typically prescribed at a dosage of 300 mg taken nightly. This dosage is effective in treating the infection while considering the safety and health of both the mother and the developing fetus. The recommendation for a single nightly dose helps to maintain effective levels of the medication throughout the night, promoting better adherence to the treatment regimen and reducing the likelihood of side effects that can occur with higher doses or more frequent administration.

During pregnancy, especially in the third trimester, it's crucial to use medications that are safe and effective. Trimethoprim is often chosen for its efficacy against common uropathogens that cause UTIs, but the dosage must be carefully calibrated to balance efficacy with safety, particularly for pregnant individuals.