What is the drug of choice for a woman with Mastitis who has no history of Penicillin allergy?

Flucloxacillin is the drug of choice for treating mastitis in women who do not have a history of penicillin allergy. This antibiotic is a type of penicillin that is particularly effective against Staphylococcus aureus, which is often the causative organism in cases of mastitis. Flucloxacillin works by inhibiting bacterial cell wall synthesis, leading to the death of the bacteria.

In cases of mastitis, particularly when it may be caused by Staphylococcus bacteria, flucloxacillin effectively targets these pathogens and offers a good therapeutic option, especially when considering the safety and overall efficacy for breastfeeding mothers. Additionally, it is less likely to cause disruption to the gut flora compared to some other antibiotics, making it a preferred choice for lactating women.

While other options may be useful in different contexts or for different infections, they are not typically considered first-line treatments for mastitis. Amoxicillin is effective but less specific to the types of bacteria usually responsible for mastitis. Cephalexin, a first-generation cephalosporin, might be a suitable alternative but is not as effective against Staphylococcus aureus as flucloxacillin. Clindamycin can be used in cases of penicillin